Givinostat hydrochloride
CAS No. 199657-29-9
Givinostat hydrochloride ( Givinostat HCl; ITF2357; ITF-2357; ITF 2357; ITF2357 HCl; ITF2357 hydrochloride )
产品货号. M28554 CAS No. 199657-29-9
Givinostat hydrochloride is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥770 | 有现货 |
|
5MG | ¥1102 | 有现货 |
|
10MG | ¥1839 | 有现货 |
|
25MG | ¥3864 | 有现货 |
|
50MG | ¥5654 | 有现货 |
|
100MG | ¥8043 | 有现货 |
|
500MG | ¥16119 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Givinostat hydrochloride
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Givinostat hydrochloride is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities.
-
产品描述Givinostat hydrochloride is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities.(In Vitro):Givinostat hydrochloride inhibits JS-1 cell proliferation in a concentration-dependent manner. Givinostat hydrochloride (≥500 nM) is associated with significant inhibition of JS-1 cell proliferation. Also, the cell inhibition rate significantly differs between the group cotreated with Givinostat hydrochloride ≥250 nM plus LPS and the group without LPS treatment. Givinostat hydrochloride (25, 50, and 100 nM) reduces IL-1β secretion more than 70%. Givinostat hydrochloride suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM, but at 100 and 200 nM, there is no reduction.(In Vivo):Givinostat hydrochloride (10 mg/kg) reduces serum TNFα by 60%. Pretreatment of Givinostat hydrochloride (0.1 mg/kg) significantly reduces the circulating TNFα by nearly 90%.
-
同义词Givinostat HCl; ITF2357; ITF-2357; ITF 2357; ITF2357 HCl; ITF2357 hydrochloride
-
通路Cell Cycle/DNA Damage
-
靶点HDAC
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number199657-29-9
-
分子量458.0
-
分子式C24H28ClN3O4
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCl.CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Toth S, et al. The effect of Betanin parenteral pretreatment on Jejunal and pulmonary tissue histological architecture and inflammatory response after Jejunal ischemia-reperfusion injury. Exp Mol Pathol. 2019 Aug 1;110:104292.
产品手册
关联产品
-
MC-1568
A potent and selective class IIa HDAC inhibitor with IC50 of 220 nM for maize HD1-A.
-
BRD6688
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes.
-
AES-135
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.